Assay Detail
Binding
CHEMBL5127308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin in human blood using fluorogenic Ac-FVR-AMC as substrate by chromogenic assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.31 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 8.58 |
| CHEMBL3415215 | — | — | 1 | 8.47 |
| CHEMBL3415211 | — | — | 1 | 8.31 |
| CHEMBL3415064 | — | — | 1 | 8.25 |
| CHEMBL3415065 | — | — | 1 | 8.14 |
| CHEMBL3415210 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48361 | DABIGATRAN | IC50 | = | 2.61 | nM | 8.58 |
| CHEMBL3415215 | — | IC50 | = | 3.39 | nM | 8.47 |
| CHEMBL3415211 | — | IC50 | = | 4.92 | nM | 8.31 |
| CHEMBL3415064 | — | IC50 | = | 5.63 | nM | 8.25 |
| CHEMBL3415065 | — | IC50 | = | 7.26 | nM | 8.14 |
| CHEMBL3415210 | — | IC50 | = | 8.4 | nM | 8.08 |