Assay Detail
Binding
CHEMBL5127309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin in human blood using fluorogenic Ac-FVR-AMC as substrate incubated for 10 mins by fluorescence based microplate reader method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.24 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3740288 | — | — | 1 | 8.45 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3740288 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 9.46 | nM | 8.02 |