Assay Detail
Binding
CHEMBL5127637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from guinea pig brain membrane KOP incubated for 1 hr by scintillation counter analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.41 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2396991 | — | — | 1 | 7.75 |
| CHEMBL5178271 | — | — | 1 | 7.54 |
| CHEMBL5187788 | — | — | 1 | 7.26 |
| CHEMBL5178409 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2396991 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL5178271 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5187788 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL5178409 | — | Ki | = | 85.0 | nM | 7.07 |