Assay Detail
Binding
CHEMBL5127752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tankyrase 2 (unknown origin) incubated for 1 hr by chemiluminescence based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-2 (CHEMBL6154) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.29 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176874 | — | — | 1 | 8.38 |
| CHEMBL5188771 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176874 | — | IC50 | = | 4.15 | nM | 8.38 |
| CHEMBL5188771 | — | IC50 | = | 6.45 | nM | 8.19 |