Assay Detail
Functional
CHEMBL5127754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell proliferation in human HCT-116 cells incubated for 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744783 | — | — | 1 | 7.03 |
| CHEMBL4758337 | — | — | 1 | 6.71 |
| CHEMBL4438741 | — | — | 1 | 6.68 |
| CHEMBL4541731 | — | — | 1 | 6.47 |
| CHEMBL4470724 | — | — | 1 | 6.11 |
| CHEMBL4461382 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744783 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4758337 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4438741 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4541731 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL4470724 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL4461382 | — | IC50 | = | 1050.0 | nM | 5.98 |