Assay Detail
Binding
CHEMBL5127797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at CRBN/recombinant WEE1 (unknown origin) assessed as induction of WEE1 degradation by FRET based Lantha Screen assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Serine/threonine-protein kinase WEE1 (CHEMBL4630732) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.45 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638510 | — | — | 1 | 8.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638510 | — | IC50 | = | 3.58 | nM | 8.45 |