Assay Detail
Binding
CHEMBL5127801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NPC1-like intracellular cholesterol transporter 1 (CHEMBL2027) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.43 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1138 | EZETIMIBE | 4.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1138 | EZETIMIBE | IC50 | = | 370.0 | nM | 6.43 |