Assay Detail
Binding
CHEMBL5127826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac activity at CRBN/Estrogen receptor in human breast cancer cells assessed as induction of estrogen receptor degradation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Breast |
| Cell Type | Breast carcinoma cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Estrogen receptor (CHEMBL4523681) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Emerging targeted protein degradation tools for innovative drug discovery: From classical PROTACs to the novel and beyond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095210 | VEPDEGESTRANT | 3.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095210 | VEPDEGESTRANT | EC50 | = | 2.0 | nM | 8.70 |