Assay Detail
Binding
CHEMBL5127947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CM7 sensor chip immobilized partial-length JMJD1C (2274 to 2498 residues) (unknown origin) expressed in Escherichia coli assessed as dissociation constant incubated for 60 secs by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable JmjC domain-containing histone demethylation protein 2C (CHEMBL3792271) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.08 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193187 | — | — | 1 | 5.57 |
| CHEMBL5173150 | — | — | 1 | 5.09 |
| CHEMBL5191875 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193187 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL5173150 | — | Kd | = | 8060.0 | nM | 5.09 |
| CHEMBL5191875 | — | Kd | = | 26700.0 | nM | 4.57 |