Assay Detail
Binding
CHEMBL5127948
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Binding affinity to CM7 sensor chip immobilized full-length KDM3B (unknown origin) expressed in Sf9 insect cells assessed as dissociation constant incubated for 60 secs by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.60 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193187 | — | — | 1 | 6.89 |
| CHEMBL5173150 | — | — | 1 | 5.11 |
| CHEMBL5191875 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193187 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL5173150 | — | Kd | = | 7790.0 | nM | 5.11 |
| CHEMBL5191875 | — | Kd | = | 16300.0 | nM | 4.79 |