Assay Detail
Binding
CHEMBL5127963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM4A (1 to 359 residues) (unknown origin) using ARTKQTARK(me3)-STGGKAPRKQLA-GGK(biotin) peptide as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LANCE Ultra assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.32 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550348 | DEFERASIROX | 4.0 | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550348 | DEFERASIROX | IC50 | = | 4760.0 | nM | 5.32 |