Assay Detail
Binding
CHEMBL5127983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NEDD8-activating enzyme E1 regulatory subunit (CHEMBL2016431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
NAE modulators: A potential therapy for gastric carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.45 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640167 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640167 | — | EC50 | = | 3560.0 | nM | 5.45 |