Assay Detail
Binding
CHEMBL5128065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Rolipram from full-length recombinant human PDE4 expressed in yeast membrane by liquid scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.70 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169957 | — | — | 1 | 8.80 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169957 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 2.512 | nM | 8.60 |