Assay Detail
Functional
CHEMBL5128286
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Antiviral activity against Ebola virus pseudotyped infected in HEK293T cells assessed as reduction in viral cytopathic effect
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent applications of vinyl sulfone motif in drug design and discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.26 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190923 | — | — | 1 | 10.40 |
| CHEMBL5185113 | — | — | 1 | 10.40 |
| CHEMBL5181012 | — | — | 1 | 10.40 |
| CHEMBL5198546 | — | — | 1 | 10.40 |
| CHEMBL4743491 | — | — | 1 | 10.40 |
| CHEMBL4755358 | — | — | 1 | 10.40 |
| CHEMBL91704 | K-777 | 2.0 | 1 | 9.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190923 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5185113 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5181012 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5198546 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4743491 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4755358 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL91704 | K-777 | IC50 | = | 0.36 | nM | 9.44 |