Assay Detail

CHEMBL5128368

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Binding

Inhibition of yeast alpha-glucosidase

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Saccharomyces cerevisiae
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.

Simone MI, Wood A, Campkin D, Kiefel MJ, Houston TA.
Eur J Med Chem (2022) 235 : 114282 -114282
PubMed 35367706 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.28	5.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1222250	DEXTROSE	4.0	1	5.58
CHEMBL44	GENISTEIN	2.0	1	4.98

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1222250	DEXTROSE	IC50	=	2600.0	nM	5.58
CHEMBL44	GENISTEIN	IC50	=	10400.0	nM	4.98