Compound Detail

CHEMBL1222250

DEXTROSE

💊 Approved Drug

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💊 Approved Drug

OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1222250
Name	DEXTROSE
Phase	Approved
Structure Type	MOL
InChI Key	WQZGKKKJIJFFOK-GASJEMHNSA-N

Known Names

Anhydrous dextrose Anhydrous glucose Capd Clintec D-glucose, anhydrous D5W Dextro energy Dextrogel Dextrose Dextrose anhydrous Dextrose component of navstel Dextrose solution +17 more

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

180.2

MW (Da)

-3.22

ALogP

HBA

HBD

110.4

PSA (Å²)

0.29

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1982
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Parenteral

Flags

Natural Product

Extended Properties

Molecular Formula	C6H12O6
MW	180.16
Aromatic Rings	0
Heavy Atoms	12
NP-Likeness	2.63

Indications

Hemorrhage Varicose Veins Angina, Unstable Breast Neoplasms Carcinoma, Hepatocellular Carpal Tunnel Syndrome Coronary Disease Epilepsy Heart Failure Heart Failure Hyponatremia Ileus Influenza, Human Kidney Failure, Chronic Kidney Failure, Chronic Liver Diseases Lymphoma, B-Cell, Marginal Zone Multiple Sclerosis Myocardial Infarction Neutropenia

ATC Classification

B05CX01

glucose

Level 1: BLOOD AND BLOOD FORMING ORGANS

Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

C05BB56

glucose, combinations

Level 1: CARDIOVASCULAR SYSTEM

Level 2: VASOPROTECTIVES

V04CA02

glucose

Level 1: VARIOUS

Level 2: DIAGNOSTIC AGENTS

V06DC01

glucose

Level 1: VARIOUS

Level 2: GENERAL NUTRIENTS

Activity Summary

Ki 10 meas.

EC50 4 meas.

IC50 1 meas. best 5.58

Kd 1 meas. best 6.54

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Unchecked CHEMBL612545	Kd	6.54	6.54	290.0	1
Unchecked CHEMBL612545	IC50	5.58	5.58	2600.0	1

Pharmacokinetic Data

Parameter	Value	Units	Species
F	100.0	%	Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Unchecked	Kd	=	290.0	nM	6.54	Binding affinity to Escherichia coli glucose/galactose binding protein by NMR an...	24913411
Unchecked	IC50	=	2600.0	nM	5.58	Inhibition of yeast alpha-glucosidase	35367706

Literature References

PubMed	DOI	Target Context	# Activities
7205876	10.1021/jm00133a012	Ovis aries	5
25238173	10.1016/j.ejmech.2014.09.031	Amyloid-beta precursor protein	4
20014752	10.1021/tx900326k	Hepatotoxicity	3
29398539	10.1016/j.bmcl.2018.01.040	Lipopolysaccharide heptosyltransferase 1	3
10377222	10.1021/jm980515p	Unchecked	2
17905738	10.1074/jbc.m706950200	Cryptosporidium parvum	2
17905738	10.1074/jbc.m706950200	Cryptosporidium hominis	2
10966742	10.1021/jm000941m	Unchecked	2
25092521	10.1016/j.bmc.2014.06.058	Glycogen phosphorylase, liver form	2
12213058	10.1021/jm020808p	Glycogen phosphorylase, brain form	2
17905738	10.1074/jbc.m706950200	Unchecked	2
10841786	10.1021/jm991156g	Liposome	2
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
19049348	10.1021/jm8008713	Unchecked	2
20373811	10.1021/jm901846t	No relevant target	2
15844957	10.1021/np0495985	NON-PROTEIN TARGET	2
9836611	10.1021/jm9810102	No relevant target	2
26948801	10.1016/j.drudis.2016.02.015	Homo sapiens	2
9154968	10.1021/jm9608016	Glycogen phosphorylase, brain form	1
-	10.5281/zenodo.7360656	Solute carrier family 2, facilitated glucose transporter member 3	1

Data from ChEMBL 36 via Core Engine