Assay Detail
Binding
CHEMBL5128513
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged SIRT5 (unknown origin) incubated for 5 mins by HPLC based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.19 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195473 | — | — | 1 | 5.22 |
| CHEMBL4864451 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195473 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4864451 | — | IC50 | = | 7000.0 | nM | 5.16 |