Assay Detail
Functional
CHEMBL5128611
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Antagonist activity at human adenosine A2A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.81 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170337 | — | — | 1 | 9.66 |
| CHEMBL184309 | — | — | 1 | 8.40 |
| CHEMBL2105747 | TOZADENANT | 3.0 | 1 | 7.96 |
| CHEMBL5182020 | — | — | 1 | 7.27 |
| CHEMBL411329 | (R,S)-MEFLOQUINE | — | 1 | 7.21 |
| CHEMBL426738 | — | — | 1 | 7.20 |
| CHEMBL189192 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170337 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL184309 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2105747 | TOZADENANT | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5182020 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL411329 | (R,S)-MEFLOQUINE | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL426738 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL189192 | — | Ki | = | 100.0 | nM | 7.00 |