Assay Detail
Functional
CHEMBL5128764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 YU2 (R4) infected in human TZM-bl cells assessed as reduction in viral replication
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.56 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137752 | — | — | 1 | 5.24 |
| CHEMBL5178959 | — | — | 1 | 4.80 |
| CHEMBL5169972 | — | — | 1 | 4.60 |
| CHEMBL5201771 | — | — | 1 | 4.40 |
| CHEMBL5207868 | — | — | 1 | 4.38 |
| CHEMBL5186619 | — | — | 1 | 4.37 |
| CHEMBL7447 | — | — | 1 | 4.10 |
| CHEMBL5176770 | — | — | 1 | - |
| CHEMBL5195114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137752 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5178959 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5169972 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5201771 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5207868 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL5186619 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL7447 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5176770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5195114 | — | IC50 | > | 100000.0 | nM | - |