Assay Detail
Functional
CHEMBL5128765
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Antiviral activity against HIV-1 NL4-3(X4) infected in human TZM-bl cells assessed as reduction in viral replication
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.93 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7447 | — | — | 1 | 6.57 |
| CHEMBL137752 | — | — | 1 | 6.50 |
| CHEMBL5178959 | — | — | 1 | 6.30 |
| CHEMBL5169972 | — | — | 1 | 5.77 |
| CHEMBL5207868 | — | — | 1 | 5.50 |
| CHEMBL5186619 | — | — | 1 | 5.43 |
| CHEMBL5201771 | — | — | 1 | 5.41 |
| CHEMBL5176770 | — | — | 1 | - |
| CHEMBL5195114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7447 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL137752 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5178959 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5169972 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5207868 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5186619 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5201771 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5176770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5195114 | — | IC50 | > | 100000.0 | nM | - |