Assay Detail
Functional
CHEMBL5129174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (2-(pyrrolidin-1-yl)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone as a novel potent tubulin depolymerizing and vascular disrupting agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.77 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.96 |
| CHEMBL5207073 | — | — | 1 | 7.68 |
| CHEMBL5201461 | — | — | 1 | 7.58 |
| CHEMBL5190462 | — | — | 1 | 6.94 |
| CHEMBL4573023 | — | — | 1 | 6.82 |
| CHEMBL5200565 | — | — | 1 | 6.65 |
| CHEMBL5192090 | — | — | 1 | 6.56 |
| CHEMBL5188845 | — | — | 1 | 6.53 |
| CHEMBL5171941 | — | — | 1 | 6.51 |
| CHEMBL5202144 | — | — | 1 | 6.48 |
| CHEMBL5204775 | — | — | 1 | 6.29 |
| CHEMBL5207171 | — | — | 1 | 6.21 |
| CHEMBL5189976 | — | — | 1 | 5.85 |
| CHEMBL5188844 | — | — | 1 | 5.76 |
| CHEMBL5200116 | — | — | 1 | - |
| CHEMBL5206348 | — | — | 1 | - |
| CHEMBL5205162 | — | — | 1 | - |
| CHEMBL5201752 | — | — | 1 | - |
| CHEMBL5181109 | — | — | 1 | - |
| CHEMBL5206410 | — | — | 1 | - |
| CHEMBL5186359 | — | — | 1 | - |
| CHEMBL5190251 | — | — | 1 | - |
| CHEMBL5206218 | — | — | 1 | - |
| CHEMBL5176892 | — | — | 1 | - |
| CHEMBL5182439 | — | — | 1 | - |
| CHEMBL5204134 | — | — | 1 | - |
| CHEMBL5188252 | — | — | 1 | - |
| CHEMBL5206826 | — | — | 1 | - |
| CHEMBL5184735 | — | — | 1 | - |
| CHEMBL5172600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5207073 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5201461 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5190462 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4573023 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5200565 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5192090 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL5188845 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL5171941 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5202144 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL5204775 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL5207171 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL5189976 | — | IC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL5188844 | — | IC50 | = | 1742.0 | nM | 5.76 |
| CHEMBL5201422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5200116 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206348 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5205162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5201752 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5181109 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206410 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5186359 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5190251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206218 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5176892 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5182439 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5204134 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188252 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206826 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5184735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172600 | — | IC50 | > | 10000.0 | nM | - |