Assay Detail
Binding
CHEMBL5129336
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Binding affinity to biotin labeled hairpin DNA 5'-GAATTC-3' (unknown origin) assessed as equilibrium dissociation constant by sensor chip immobilization based surface plasmon resonance analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.95 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232046 | — | — | 1 | 8.82 |
| CHEMBL4853880 | — | — | 1 | 8.19 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232046 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL4853880 | — | Kd | = | 6.5 | nM | 8.19 |
| CHEMBL24057 | FURAMIDINE | Kd | = | 140.0 | nM | 6.85 |