Assay Detail
Binding
CHEMBL5129342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human MMP-1 catalytic domain (100 to 269 residues) expressed in Escherichia coli BL21 Star (DE3) by SPR analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of flavonoid probes and the binding mode of the target protein and quercetin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.48 | 4.66 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163316 | 3-O-METHYLQUERCETIN | — | 2 | 4.66 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163316 | 3-O-METHYLQUERCETIN | Kd | = | 21700.0 | nM | 4.66 |
| CHEMBL50 | QUERCETIN | Kd | = | 51800.0 | nM | 4.29 |
| CHEMBL50 | QUERCETIN | Activity | - | — | - | |
| CHEMBL163316 | 3-O-METHYLQUERCETIN | Activity | - | — | - |