Assay Detail
Binding
CHEMBL5129724
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Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Expi293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.78 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | — | 1 | 9.40 |
| CHEMBL1256672 | — | — | 1 | 7.12 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 6.82 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | - |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | Ki | = | 0.395 | nM | 9.40 |
| CHEMBL1256672 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL477 | ADENOSINE | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | - | — | - | |
| CHEMBL1467 | ALLOPURINOL | Ki | - | — | - | |
| CHEMBL113 | CAFFEINE | Ki | - | — | - |