Assay Detail
Binding
CHEMBL5129754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PLK1 (unknown origin) in the presence of ATP by ADP-Glo-kinase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.08 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402227 | — | — | 1 | 5.20 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.05 |
| CHEMBL2235239 | Moslosooflavone | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402227 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2235239 | Moslosooflavone | IC50 | = | 10200.0 | nM | 4.99 |