Assay Detail
Binding
CHEMBL5129799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cell membrane measured after 2 hr by Cheng-prusoff equation analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β<sub>2</sub> Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.71 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172865 | — | — | 1 | 10.20 |
| CHEMBL5190387 | — | — | 1 | 10.20 |
| CHEMBL5193853 | — | — | 1 | 10.10 |
| CHEMBL4854091 | — | — | 1 | 9.90 |
| CHEMBL5184455 | — | — | 1 | 9.90 |
| CHEMBL5208957 | — | — | 1 | 9.80 |
| CHEMBL5200887 | — | — | 1 | 9.70 |
| CHEMBL5208201 | — | — | 1 | 9.50 |
| CHEMBL5200448 | — | — | 1 | 9.10 |
| CHEMBL5184598 | — | — | 1 | 9.10 |
| CHEMBL5177499 | — | — | 1 | 9.00 |
| CHEMBL5195203 | — | — | 1 | 8.80 |
| CHEMBL5179380 | — | — | 1 | 8.50 |
| CHEMBL5178217 | — | — | 1 | 8.50 |
| CHEMBL5187593 | — | — | 1 | 8.40 |
| CHEMBL5194569 | — | — | 1 | 8.40 |
| CHEMBL5193776 | — | — | 1 | 8.30 |
| CHEMBL5202045 | — | — | 1 | 8.20 |
| CHEMBL5195224 | — | — | 1 | 8.10 |
| CHEMBL5181855 | — | — | 1 | 8.10 |
| CHEMBL5202787 | — | — | 1 | 8.10 |
| CHEMBL5202567 | — | — | 1 | 8.10 |
| CHEMBL5207792 | — | — | 1 | 8.00 |
| CHEMBL5170720 | — | — | 1 | 7.60 |
| CHEMBL5193865 | — | — | 1 | 7.60 |
| CHEMBL5203937 | — | — | 1 | 7.40 |
| CHEMBL5180420 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172865 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL5190387 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL5193853 | — | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL4854091 | — | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL5184455 | — | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL5208957 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL5200887 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL5208201 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL5200448 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL5184598 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL5177499 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5195203 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL5179380 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL5178217 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL5187593 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL5194569 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL5193776 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL5202045 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL5195224 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL5181855 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL5202787 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL5202567 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL5207792 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5170720 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL5193865 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL5203937 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL5180420 | — | Ki | = | 199.53 | nM | 6.70 |