Assay Detail
Binding
CHEMBL5129832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CaV1.2 channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL1940) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β<sub>2</sub> Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172865 | — | — | 1 | 4.30 |
| CHEMBL5201712 | — | — | 1 | - |
| CHEMBL5203937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172865 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5201712 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5203937 | — | IC50 | > | 100000.0 | nM | - |