Assay Detail
Binding
CHEMBL5130123
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) (CHEMBL2221348) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.28 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204124 | — | — | 1 | 5.50 |
| CHEMBL4438095 | — | — | 1 | 5.40 |
| CHEMBL41355 | EZOGABINE | 4.0 | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204124 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4438095 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL41355 | EZOGABINE | EC50 | = | 11200.0 | nM | 4.95 |