Assay Detail
Binding
CHEMBL5130682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of thiazole orange from c-kit1 G4 quadruplex d(DNA AGG GAG GGC GCT GGG AGG AGG G) DNA (unknown origin) assessed as relative affinity by fluorescent intercalator displacement assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.81 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191417 | — | — | 1 | 5.92 |
| CHEMBL5180396 | — | — | 1 | 5.89 |
| CHEMBL5177572 | — | — | 1 | 5.85 |
| CHEMBL5182391 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191417 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5180396 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5177572 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5182391 | — | IC50 | = | 2700.0 | nM | 5.57 |