Assay Detail
Binding
CHEMBL5130697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC4 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3692671 | — | — | 1 | 8.52 |
| CHEMBL4456445 | — | — | 1 | 7.27 |
| CHEMBL5172806 | — | — | 1 | 7.05 |
| CHEMBL5208515 | — | — | 1 | 7.04 |
| CHEMBL5199458 | — | — | 1 | 7.00 |
| CHEMBL5206361 | — | — | 1 | 6.82 |
| CHEMBL5191938 | — | — | 1 | 6.64 |
| CHEMBL5194487 | — | — | 1 | 6.39 |
| CHEMBL5202426 | — | — | 1 | 6.25 |
| CHEMBL5181194 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3692671 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4456445 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5172806 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5208515 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5199458 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5206361 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5191938 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5194487 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5202426 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5181194 | — | IC50 | = | 1100.0 | nM | 5.96 |