Assay Detail
Binding
CHEMBL5130698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HDAC5 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.94 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3692671 | — | — | 1 | 8.30 |
| CHEMBL4456445 | — | — | 1 | 7.22 |
| CHEMBL5172806 | — | — | 1 | 6.85 |
| CHEMBL5208515 | — | — | 1 | 6.82 |
| CHEMBL5194487 | — | — | 1 | 6.64 |
| CHEMBL5199458 | — | — | 1 | 6.60 |
| CHEMBL5181194 | — | — | 1 | 6.58 |
| CHEMBL5202426 | — | — | 1 | 6.51 |
| CHEMBL5191938 | — | — | 1 | - |
| CHEMBL5206361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3692671 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4456445 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5172806 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5208515 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5194487 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5199458 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5181194 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5202426 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5191938 | — | IC50 | - | — | - | |
| CHEMBL5206361 | — | IC50 | - | — | - |