Assay Detail
Binding
CHEMBL5131159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Plasmepsin X (CHEMBL4523390) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.50 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171401 | — | — | 1 | 10.52 |
| CHEMBL5182418 | — | — | 1 | 10.22 |
| CHEMBL5187792 | — | — | 1 | 10.15 |
| CHEMBL5193119 | — | — | 1 | 9.52 |
| CHEMBL5199100 | — | — | 1 | 9.40 |
| CHEMBL5207556 | — | — | 1 | 9.22 |
| CHEMBL5197877 | — | — | 1 | 8.72 |
| CHEMBL5178733 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171401 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5182418 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5187792 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5193119 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5199100 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5207556 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5197877 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5178733 | — | IC50 | = | 5.7 | nM | 8.24 |