Assay Detail
Binding
CHEMBL5131241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1/JAK3 in CD3+ T cells (unknown origin) assessed as reduction in IL-2 stimulated STAT5 phosphorylation incubated for 1.5 hrs by HTRF assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CD3-positive T cell |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel TYK2 Inhibitors with an <i>N</i>-(Methyl-<i>d</i> <sub>3</sub>)pyridazine-3-carboxamide Skeleton for the Treatment of Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.39 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191508 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191508 | — | IC50 | = | 41.0 | nM | 7.39 |