Assay Detail
Toxicity
CHEMBL5131352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human EA.hy 926 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A New Naphthopyran Derivative Combines <i>c</i>-Myb Inhibition, Microtubule-Targeting Effects, and Antiangiogenic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184353 | — | — | 1 | 8.21 |
| CHEMBL5176963 | — | — | 1 | 7.92 |
| CHEMBL5198083 | — | — | 1 | 7.80 |
| CHEMBL5188413 | — | — | 1 | 7.77 |
| CHEMBL228363 | — | — | 1 | 7.70 |
| CHEMBL321336 | — | — | 1 | 7.53 |
| CHEMBL5203253 | — | — | 1 | 7.18 |
| CHEMBL5176572 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184353 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5176963 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL5198083 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5188413 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL228363 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL321336 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL5203253 | — | IC50 | = | 65.8 | nM | 7.18 |
| CHEMBL5176572 | — | IC50 | = | 78.0 | nM | 7.11 |