Assay Detail

CHEMBL5131614

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Binding

Inhibition of BTK (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase BTK (CHEMBL5251) ↗

Open DB target context

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Tyrosine-protein kinase BTK (CHEMBL5251) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase BTK

CHEMBL5251

Anchored from Assay target.

Protein identity Tyrosine-protein kinase BTK

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase BTK (CHEMBL5251) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.

Raghuvanshi R, Bharate SB.
J Med Chem (2022) 65 : 893 -921
PubMed 33539089 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	9.43	9.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3936761	ZANUBRUTINIB	4.0	1	9.52
CHEMBL1873475	IBRUTINIB	4.0	1	9.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3936761	ZANUBRUTINIB	IC50	=	0.3	nM	9.52
CHEMBL1873475	IBRUTINIB	IC50	=	0.46	nM	9.34