Assay Detail
Binding
CHEMBL5131641
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Inhibition of JAK 3 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.30 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4238926 | — | — | 1 | 9.15 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.00 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.96 |
| CHEMBL4116008 | CERDULATINIB | 2.0 | 1 | 8.10 |
| CHEMBL4297507 | DELGOCITINIB | 3.0 | 1 | 7.89 |
| CHEMBL4650343 | IZENCITINIB | 2.0 | 1 | 7.50 |
| CHEMBL4085457 | RITLECITINIB | 4.0 | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4238926 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL495727 | AT-9283 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4116008 | CERDULATINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4297507 | DELGOCITINIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4650343 | IZENCITINIB | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4085457 | RITLECITINIB | IC50 | = | 33.1 | nM | 7.48 |