Assay Detail
Binding
CHEMBL5131722
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Inhibition of MEK1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.98 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | 4.0 | 1 | 9.04 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 7.77 |
| CHEMBL34704 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL105442 | CI-1040 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL34704 | — | IC50 | = | 72.0 | nM | 7.14 |