Assay Detail
Binding
CHEMBL5131747
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Inhibition of AAK1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439128 | — | — | 1 | 8.40 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 7.77 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 7.50 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 7.00 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439128 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 200.0 | nM | 6.70 |