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Assay Detail

CHEMBL5131963

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to AAK1 (unknown origin) assessed as dissociation constant
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

AP2-associated protein kinase 1 (CHEMBL3830)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Kinase Inhibitors as Underexplored Antiviral Agents.
García-Cárceles J, Caballero E, Gil C, Martínez A.
J Med Chem (2022) 65 : 935 -954
PubMed 33970631 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 11 7.96 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5200929 1 9.00
CHEMBL5184366 1 9.00
CHEMBL4439128 1 8.40
CHEMBL2105759 BARICITINIB 4.0 1 8.09
CHEMBL4452939 1 8.04
CHEMBL535 SUNITINIB 4.0 1 7.96
CHEMBL516312 1 7.28
CHEMBL553 ERLOTINIB 4.0 1 5.92
CHEMBL4458078 1 -
CHEMBL5416410 DASATINIB 4.0 1 -
CHEMBL939 GEFITINIB 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5200929 Kd = 1.0 nM 9.00
CHEMBL5184366 Kd = 1.0 nM 9.00
CHEMBL4439128 Kd = 4.0 nM 8.40
CHEMBL2105759 BARICITINIB Kd = 8.2 nM 8.09
CHEMBL4452939 Kd = 9.1 nM 8.04
CHEMBL535 SUNITINIB Kd = 11.0 nM 7.96
CHEMBL516312 Kd = 53.0 nM 7.28
CHEMBL553 ERLOTINIB Kd = 1200.0 nM 5.92
CHEMBL4458078 Kd = 18000000.0 nM -
CHEMBL5416410 DASATINIB Kd > 3000.0 nM -
CHEMBL939 GEFITINIB Kd > 3000.0 nM -