Assay Detail
Binding
CHEMBL5132491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FTO (unknown origin) demethylation activity by HPLC assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.44 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196484 | — | — | 1 | 7.06 |
| CHEMBL5183243 | — | — | 1 | 6.24 |
| CHEMBL5173876 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196484 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5183243 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5173876 | — | IC50 | = | 930.0 | nM | 6.03 |