Assay Detail
Binding
CHEMBL5133363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli DNA gyrase by fluorescence based microtiter plate reader assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.45 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.64 |
| CHEMBL2158050 | — | — | 1 | 5.41 |
| CHEMBL5176134 | — | — | 1 | 5.27 |
| CHEMBL5178214 | — | — | 1 | 5.19 |
| CHEMBL5183842 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2158050 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5176134 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5178214 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL5183842 | — | IC50 | = | 18420.0 | nM | 4.74 |