Assay Detail
Functional
CHEMBL5133516
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Antiproliferative activity against human A-431 cells overexpressing EGFR assessed as cell growth inhibition by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.10 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478960 | MACLURAXANTHONE | — | 1 | 5.55 |
| CHEMBL5192793 | — | — | 1 | 5.42 |
| CHEMBL5181037 | — | — | 1 | 5.22 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.14 |
| CHEMBL5185036 | — | — | 1 | 4.75 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478960 | MACLURAXANTHONE | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL5192793 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5181037 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL323197 | MANGOSTIN | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5185036 | — | IC50 | = | 17710.0 | nM | 4.75 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 31940.0 | nM | 4.50 |