Assay Detail
Binding
CHEMBL5133629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from Sprague-Dawley rat brain membrane mu opioid receptor incubated for 45 mins by liquid scintillation counting analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.59 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 8.83 |
| CHEMBL5194022 | — | — | 1 | 6.09 |
| CHEMBL5178450 | — | — | 1 | 5.84 |
| CHEMBL5194121 | — | — | 1 | 5.59 |
| CHEMBL3596572 | — | — | 1 | - |
| CHEMBL335258 | TEREPHTHALAMIC ACID | — | 1 | - |
| CHEMBL5192985 | — | — | 1 | - |
| CHEMBL5198792 | — | — | 1 | - |
| CHEMBL5205647 | — | — | 1 | - |
| CHEMBL5190377 | — | — | 1 | - |
| CHEMBL5203238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL5194022 | — | Ki | = | 817.0 | nM | 6.09 |
| CHEMBL5178450 | — | Ki | = | 1458.0 | nM | 5.84 |
| CHEMBL5194121 | — | Ki | = | 2551.0 | nM | 5.59 |
| CHEMBL3596572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL335258 | TEREPHTHALAMIC ACID | Ki | > | 10000.0 | nM | - |
| CHEMBL5192985 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5198792 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5205647 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5190377 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5203238 | — | Ki | > | 10000.0 | nM | - |