Assay Detail
Binding
CHEMBL5133661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE by Ellman's method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit epsilon (CHEMBL2484) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.27 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179810 | — | — | 1 | 8.64 |
| CHEMBL5204683 | — | — | 1 | 7.92 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.49 |
| CHEMBL5181578 | — | — | 1 | 7.49 |
| CHEMBL5176418 | — | — | 1 | 7.44 |
| CHEMBL5173121 | — | — | 1 | 7.36 |
| CHEMBL5207035 | — | — | 1 | 7.24 |
| CHEMBL5190924 | — | — | 1 | 7.15 |
| CHEMBL5188135 | — | — | 1 | 7.08 |
| CHEMBL5200573 | — | — | 1 | 7.06 |
| CHEMBL5179648 | — | — | 1 | 7.04 |
| CHEMBL5196896 | — | — | 1 | 6.39 |
| CHEMBL5206933 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179810 | — | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL5204683 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL5181578 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL5176418 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL5173121 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL5207035 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL5190924 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL5188135 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL5200573 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL5179648 | — | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL5196896 | — | IC50 | = | 407.38 | nM | 6.39 |
| CHEMBL5206933 | — | IC50 | = | 676.08 | nM | 6.17 |