Assay Detail
Functional
CHEMBL5133868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at OX2R (unknown origin)
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.47 | 9.24 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203887 | — | — | 1 | 9.24 |
| CHEMBL5205313 | — | — | 1 | 8.82 |
| CHEMBL5204003 | — | — | 1 | 8.67 |
| CHEMBL5192814 | — | — | 1 | 8.57 |
| CHEMBL5200472 | — | — | 1 | 8.48 |
| CHEMBL5200587 | — | — | 1 | 8.45 |
| CHEMBL5171076 | — | — | 1 | 8.44 |
| CHEMBL5198468 | — | — | 1 | 8.25 |
| CHEMBL5189784 | — | — | 1 | 8.19 |
| CHEMBL5180145 | — | — | 1 | 7.97 |
| CHEMBL5201030 | — | — | 1 | 7.71 |
| CHEMBL5186755 | — | — | 1 | 7.58 |
| CHEMBL438925 | — | — | 1 | 7.47 |
| CHEMBL5175413 | — | — | 1 | 7.36 |
| CHEMBL5194511 | — | — | 1 | 7.24 |
| CHEMBL413434 | OREXIN B | — | 1 | 7.22 |
| CHEMBL5187376 | — | — | 1 | 7.11 |
| CHEMBL5197252 | — | — | 1 | 6.90 |
| CHEMBL5203080 | — | — | 1 | 6.85 |
| CHEMBL5199597 | — | — | 1 | 6.82 |
| CHEMBL5194412 | — | — | 1 | 6.65 |
| CHEMBL5187194 | — | — | 1 | 6.38 |
| CHEMBL5192028 | — | — | 1 | 6.21 |
| CHEMBL5184945 | — | — | 1 | 6.08 |
| CHEMBL5187462 | — | — | 1 | 5.72 |
| CHEMBL5179969 | — | — | 1 | 5.71 |
| CHEMBL5186006 | — | — | 1 | - |
| CHEMBL4650341 | DANAVOREXTON | 2.0 | 1 | - |
| CHEMBL5178928 | — | — | 1 | - |
| CHEMBL5186945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203887 | — | EC50 | = | 0.579 | nM | 9.24 |
| CHEMBL5205313 | — | EC50 | = | 1.51 | nM | 8.82 |
| CHEMBL5204003 | — | EC50 | = | 2.14 | nM | 8.67 |
| CHEMBL5192814 | — | EC50 | = | 2.69 | nM | 8.57 |
| CHEMBL5200472 | — | EC50 | = | 3.27 | nM | 8.48 |
| CHEMBL5200587 | — | EC50 | = | 3.59 | nM | 8.45 |
| CHEMBL5171076 | — | EC50 | = | 3.63 | nM | 8.44 |
| CHEMBL5198468 | — | EC50 | = | 5.59 | nM | 8.25 |
| CHEMBL5189784 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5180145 | — | EC50 | = | 10.7 | nM | 7.97 |
| CHEMBL5201030 | — | EC50 | = | 19.3 | nM | 7.71 |
| CHEMBL5186755 | — | EC50 | = | 26.6 | nM | 7.58 |
| CHEMBL438925 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5175413 | — | EC50 | = | 43.7 | nM | 7.36 |
| CHEMBL5194511 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL413434 | OREXIN B | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5187376 | — | EC50 | = | 78.1 | nM | 7.11 |
| CHEMBL5197252 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5203080 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5199597 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5194412 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5187194 | — | EC50 | = | 413.0 | nM | 6.38 |
| CHEMBL5192028 | — | EC50 | = | 618.0 | nM | 6.21 |
| CHEMBL5184945 | — | EC50 | = | 837.0 | nM | 6.08 |
| CHEMBL5187462 | — | EC50 | = | 1918.0 | nM | 5.72 |
| CHEMBL5179969 | — | EC50 | = | 1949.0 | nM | 5.71 |
| CHEMBL5186006 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4650341 | DANAVOREXTON | EC50 | = | 5.5 | nM | - |
| CHEMBL5178928 | — | Activity | - | — | - | |
| CHEMBL5186945 | — | Activity | - | — | - |