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Compound Detail

CHEMBL5201030

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CCN(C(=O)Cc1cccc(OC)c1)C1CCCc2ccc(NS(=O)(=O)c3cc(-c4cccc(C(=O)N(C)C)c4)ccc3OC)cc21

Basic Information

ChEMBL ID CHEMBL5201030
Phase Preclinical
Structure Type MOL
InChI Key XSUFQYDPVJKPPD-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

655.8
MW (Da)
6.34
ALogP
6
HBA
1
HBD
105.2
PSA (Ų)
0.20
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H41N3O6S
MW 655.82
Aromatic Rings 4
Heavy Atoms 47
NP-Likeness -1.38

Activity Summary

EC50 2 meas. best 7.71

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Orexin receptor type 2
CHEMBL4792
EC50 7.71 7.71 19.3 1
Orexin/Hypocretin receptor type 1
CHEMBL5113
EC50 6.45 6.45 356.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35051577 10.1016/j.bmcl.2022.128555 Orexin/Hypocretin receptor type 1 2
35051577 10.1016/j.bmcl.2022.128555 Orexin receptor type 2 2
35051577 10.1016/j.bmcl.2022.128555 Unchecked 1

Data from ChEMBL 36 via Core Engine