Assay Detail
Functional
CHEMBL5134248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 72 hrs by SYBR green I-based DNA quantification assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 54 | 6.05 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196963 | — | — | 1 | 6.50 |
| CHEMBL4522426 | — | — | 1 | 6.50 |
| CHEMBL5174640 | — | — | 1 | 6.48 |
| CHEMBL5170920 | — | — | 1 | 6.32 |
| CHEMBL5190317 | — | — | 1 | 6.31 |
| CHEMBL5199260 | — | — | 1 | 6.30 |
| CHEMBL5191813 | — | — | 1 | 6.29 |
| CHEMBL5186122 | — | — | 1 | 6.28 |
| CHEMBL5174248 | — | — | 1 | 6.28 |
| CHEMBL5175017 | — | — | 1 | 6.28 |
| CHEMBL5195685 | — | — | 1 | 6.26 |
| CHEMBL5196643 | — | — | 1 | 6.21 |
| CHEMBL5203418 | — | — | 1 | 6.20 |
| CHEMBL5207782 | — | — | 1 | 6.20 |
| CHEMBL5178294 | — | — | 1 | 6.19 |
| CHEMBL5189777 | — | — | 1 | 6.15 |
| CHEMBL5173196 | — | — | 1 | 6.07 |
| CHEMBL5179423 | — | — | 1 | 6.03 |
| CHEMBL5194726 | — | — | 1 | 5.97 |
| CHEMBL5202829 | — | — | 1 | 5.94 |
| CHEMBL5178524 | — | — | 1 | 5.92 |
| CHEMBL5182452 | — | — | 1 | 5.89 |
| CHEMBL5199689 | — | — | 1 | 5.89 |
| CHEMBL5169571 | — | — | 1 | 5.85 |
| CHEMBL5199154 | — | — | 1 | 5.83 |
| CHEMBL5169642 | — | — | 1 | 5.75 |
| CHEMBL5200483 | — | — | 1 | 5.74 |
| CHEMBL5180379 | — | — | 1 | 5.74 |
| CHEMBL5188340 | — | — | 1 | 5.72 |
| CHEMBL5192125 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196963 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4522426 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5174640 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5170920 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5190317 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5199260 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5191813 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5186122 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5174248 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5175017 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5195685 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5196643 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5203418 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5207782 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5178294 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5189777 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5173196 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5179423 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5194726 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5202829 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5178524 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5182452 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5199689 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5169571 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5199154 | — | EC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5169642 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5180379 | — | EC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5200483 | — | EC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5188340 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5192125 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL5174136 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5208646 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5209396 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5193302 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5170339 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5182285 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5206945 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5179646 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5196570 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5188456 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5202624 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5191662 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5192744 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5182609 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5191250 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5170299 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5170858 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5209149 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5171864 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL5189988 | — | EC50 | > | 2500.0 | nM | - |