Compound Detail
CHEMBL5195685
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Basic Information
| ChEMBL ID | CHEMBL5195685 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOVZASIMZDEGPT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
281.4
MW (Da)
4.02
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | EC50 | = | 550.0 | nM | 6.26 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 as... | 35091169 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35091169 | 10.1016/j.bmc.2022.116629 | No relevant target | 4 |
| 35091169 | 10.1016/j.bmc.2022.116629 | Plasmodium falciparum | 1 |
| 35091169 | 10.1016/j.bmc.2022.116629 | HepG2 | 1 |
| 35091169 | 10.1016/j.bmc.2022.116629 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine