Assay Detail
Functional
CHEMBL5135113
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 68 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.10 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189850 | — | — | 1 | 8.03 |
| CHEMBL5200911 | — | — | 1 | 8.02 |
| CHEMBL5182410 | — | — | 1 | 7.93 |
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.66 |
| CHEMBL5181962 | — | — | 1 | 7.64 |
| CHEMBL5184508 | — | — | 1 | 7.37 |
| CHEMBL433257 | HARRINGTONINE | — | 1 | 7.30 |
| CHEMBL5205099 | — | — | 1 | 6.98 |
| CHEMBL5174225 | — | — | 1 | 6.92 |
| CHEMBL5194384 | — | — | 1 | 6.73 |
| CHEMBL5191809 | — | — | 1 | 6.30 |
| CHEMBL5182991 | — | — | 1 | 6.24 |
| CHEMBL5203961 | — | — | 1 | 5.21 |
| CHEMBL4174530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189850 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5200911 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5182410 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL5181962 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL5184508 | — | IC50 | = | 42.4 | nM | 7.37 |
| CHEMBL433257 | HARRINGTONINE | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL5205099 | — | IC50 | = | 103.9 | nM | 6.98 |
| CHEMBL5174225 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5194384 | — | IC50 | = | 186.1 | nM | 6.73 |
| CHEMBL5191809 | — | IC50 | = | 498.7 | nM | 6.30 |
| CHEMBL5182991 | — | IC50 | = | 582.7 | nM | 6.24 |
| CHEMBL5203961 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4174530 | — | IC50 | > | 100000.0 | nM | - |