Assay Detail
Binding
CHEMBL5135589
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Inhibition of recombinant human HDAC6 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.20 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 7.47 |
| CHEMBL5208700 | — | — | 1 | 6.80 |
| CHEMBL5208990 | — | — | 1 | 6.75 |
| CHEMBL5181507 | — | — | 1 | 6.68 |
| CHEMBL5203383 | — | — | 1 | 6.55 |
| CHEMBL5188463 | — | — | 1 | 6.37 |
| CHEMBL5184762 | — | — | 1 | 5.85 |
| CHEMBL5201275 | — | — | 1 | 5.62 |
| CHEMBL5173958 | — | — | 1 | 5.43 |
| CHEMBL5184156 | — | — | 1 | 5.36 |
| CHEMBL5207713 | — | — | 1 | 5.32 |
| CHEMBL5201544 | — | — | 1 | - |
| CHEMBL5188225 | — | — | 1 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5208700 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5208990 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5181507 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5203383 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5188463 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5184762 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5201275 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL5173958 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5184156 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5207713 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5201544 | — | IC50 | - | — | - | |
| CHEMBL5188225 | — | IC50 | - | — | - | |
| CHEMBL2018302 | TUBASTATIN A | IC50 | - | — | - |